Linus Pauling

Correcting A Damaged Gene (GULO) With Vitamin C…

In Today’s Version of Humans We ALL Have This Defect…

 By Owen R. Fonorow – Vitamin C Foundation

Vitamin C is a panacea for many conditions due to the fact that humans evolved to require a great deal more Vitamin C than we can eat. Unlike our ancestors, we humans can no longer make Vitamin C in our bodies.

All humans are born with a genetic defect. Our livers are missing a key enzyme, xl-gulono-§-lactone oxidase, which is required to synthesize ascorbic acid from glucose. The loss of this single gene prevents humans from making their own Vitamin C. The negative mutation of the so-called GULO gene has been well studied in both human and primate genomes. If this negative mutation could be corrected, most people would no longer need to supplement Vitamin C in their diets.

Thanks to modern science, it is easy and inexpensive to correct this damaged gene by supplementing Vitamin C (ascorbic acid or one of its salts) into one’s diet.

As with any inherited malfunction, the inability to produce the GULO enzyme has negative consequences. Most people are taught to believe that they can obtain enough Vitamin C in their food, and so they supplement too little. While this ‘food argument’ generally holds true for most other vitamins, the idea that one can obtain the necessary amount of Vitamin C in food sources is countered by facts.

When compared to all of the species alive today, humans are nearly the only species with a GULO-like genetic defect.

Most living things today make their own Vitamin C and do not have to obtain it through food sources. They do this by converting glucuronic acid (C6H10O7), derived from glucose (C6H12O6), into ascorbic acid (C6H8O6). The exceptions that cannot make their own Vitamin C are guinea pigs, fruit eating bats, the red-vented bulbul bird, and higher primates, such as gorillas and humans.

With a working GULO gene, humans would make their own Vitamin C in “fantastic” amounts by today’s standards.

In the 1930s, Dr. Claus W. Jungblut, an early pioneer of Vitamin C therapy, discovered that only primates and guinea pigs were susceptible to scurvy as well as anaphylactic shock, pulmonary tuberculosis, diptheritic intoxication, a poliomyelitis-like viral infection and a viral form of leukemia. However, none of the Vitamin C synthesizing laboratory animals had susceptibility to these diseases. Gorillas in captivity are susceptible to the aforementioned set of diseases, and humans share other conditions with these primates that are not common in other species (e.g., cardiovascular disease).

Linus Pauling elucidated in his Unified Theory of Cardiovascular Disease paper, and in a video-taped lecture, that a large consequence of our genetic deficiency is our tendency to develop cardiovascular disease, which for many is a primary cause of death.

If there is one thing to know about vitamin C, it is that animals make  far more of it 24/7 than the U. S. Recommended 70 mg Dietary Allowance for human beings.

Animals produce much more Vitamin C in their bodies than what humans can obtain from the meager dosages recommended. Adjusted for body weight and under ordinary conditions, animals have been found to produce between 3,000 to 13,000 mg of ascorbic acid daily. A goat under stress may produce over 100,000 mg of ascorbic acid daily. As these animals make their own ascorbic acid, the molecule enters the blood stream intact (directly from the liver or kidney).

Ascorbate, another term now used for higher dosages of Vitamin C, is volatile and reacts easily with other substances. Because of this, some Vitamin C is lost when taken by mouth during the digestion process. Scientists have estimated that 50% or more of the Vitamin C taken by mouth may not reach the blood stream intact; therefore is not bio-available. This loss will increase as the dosage by mouth is increased.

Linus Pauling, according to a biography, did not begin taking Vitamin C until his sixth decade of life. At the age when most retire, Pauling instead became a champion of Vitamin C.

During videotaped lecture during the 1980s on Vitamin C and Cancer, Pauling stated that his personal dosage was based on his body weight and the expected loss of ascorbate taken by mouth.

Pauling wrote that his daily intake of ascorbic acid was 18,000 mg.   Pauling determined through experimentation that at this dosage, he lost approximately 50% of the Vitamin C taken by mouth during digestion. Mammals of his body weight have evolved to make 9,000 mg of Vitamin C throughout a typical day. For this reason, he doubled the dosage an animal would produce (9000 mg)  and consumed 18,000 mg daily in two divided dosages (i.e., 2 dosages of 9,000 mg twice daily). This daily dosage accounted for the loss, and approximated the blood and tissue concentrations of species that make their own ascorbate.

Linus Pauling also learned that since Vitamin C has no known toxicity, there is little risk from this high of a dosage. Pauling’s last video lecture on heart disease, which he gave without notes at the age of 92, proved to many that his mind was still sharp and exceptional. Pauling lived to the extraordinary age of 93 years old.

Take Home Message…

We may be at the onset of creating human life spans longer than 125 years! Linus Pauling anticipated that anti-aging science would discover significant longevity benefits from taking high amounts of Vitamin C. He stated this belief in his still-authoritative book, How To Live Longer and Feel Better. Pauling wrote that although he couldn’t prove it at the time, he believed that by taking his recommended high anti-oxidant regimen, especially Vitamin C, that humans could extend their period of healthy life, perhaps by 20 or 30 years.

As interest grows in the new anti-aging nutrient science and technologies, including and especially telomerase activation medicine, the importance of Vitamin C may be understated. We beg to differ. In our opinion, there is no other nutritional supplement more important for its anti-aging properties. It makes little sense to attempt to extend life while ignoring this easily correctable genetic defect. Any anti-aging and life span extending technology, in our opinion, begins with Vitamin C replacement to account for our damaged GULO gene.

By Owen R. Fonorow – Vitamin C Foundation

Published by

Owen Fonorow

In 1996, Owen founded the nonprofit Vitamin C Foundation, along with his brother Michael S. Till, Sr. Owen has since written more than thirty articles and these papers have been published in assorted alternative medical journals including the Townsend Letter for Doctors and Patients, Nexus New Times, Life Extension Foundation magazine, American Naturopathic Medical Association Monitor, Florida ECO Report, International Council for Health Freedom Newsletter and Media By-Pass. Many of the themes in these articles have been incorporated in his book, Practicing Medicine Without A License? The Story of the Linus Pauling Therapy for Heart Disease.

3 thoughts on “Correcting A Damaged Gene (GULO) With Vitamin C…”

  1. I have found through both research and experience that too much vitamin c lowers minerals in the body, especially copper. Vitamin c detoxes, and is a chelator of metals. Low copper causes excess bleeding, like scurvy. Some described this phenomenon as a rebound survey from suddenly stopping taking vitamin c. I like vitamin c. I have been taking it since age 5. I’m 49. Maybe I have a greater timespan in my life of taking vitamin c than linus pauling had.

    Pauling died from prostate cancer. Today, researchers have found 3 minerals that, alone, each can cure prostate cancer. Iodine, boron, zinc.

    Perhaps that is not a coincidence, but low minerals caused the prostate cancer, from too much vitamin c.

    You can write that science does not know of any harm of too much vitamin c. We are in the age of information. I’ve pointed you in the right directions. Keep looking.

  2. When I had my terminal diagnosis in January 1999, I went onto ten grams daily and noticed no negative effects. I was influenced by the fact that during Pauling’s experiments with terminal cancer patients and vitamin C, many of those individuals were alive several years later. Having read Ralph Moss’ ‘The Cancer Industry’ which is an utterly shocking eye opener, I took careful note of his warning that vitamin C should never be suddenly stopped. Today I take just two grams daily as a maintenance dose.

    As for pointing people ‘in the right direction’, we tend to prefer nowadays not to trust our own intuitions. I can only add that if \i relied upon the ‘experts’ it is unlikely that I would still be alive today. Ralph Moss refers in his book to a patient remaining alive many years after his terminal diagnosis by taking over seventy grams daily intravenously, whilst in the book, ‘What doctors don’t tell you’, the author describes her own mother in law who on examination by her doctor here in the UK was advised to settle her affairs. The lady is still alive, having been advised by her daughter in law to find a doctor who was prepared to inject her with large doses of vitmlin C daily.

    Vitamin C is frequently used as a food preservative, but cannot be bought in bulk here. I know because I asked Roche and they refused whilst issuing all sorts of health warnings about large doses. Almost 21 years later I remain well despite the occasional scare stories.

  3. Jason, as a matter of fact, it’s more likely that the patient [taking C and encountering a deficiency in a mineral] did NOT CAUSE THE DEFICIENCY… The problem is that the deficiency was concealed in testing because the enzymes that use that mineral were unable to use it, so the mineral accumulated in a way that the testing was measuring, concealing the breakdown in the enzymatic process.

    Do you see now, why people need more comprehensive testing? As we were just following the work of one doctor on supporting mitochondria and he had encountered such a concealed deficiency in a different pathway. He had to look at intake variables and other points of the enzyme path, as well as blood levels.

    So by all means, persist in reading and relaying ideas as well as in taking as much C as keeps you healthy.. ttyl

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